HOW DANGEROUS IS OMICRON VARIANT

 

 World Health Organization (WHO) has declared the new Omicron (or B.1.1.529) variant of the coronavirus, reported on November 24 in South Africa, to be “of concern,” stating that the likelihood of further global spread of this variant is “very high” due to its many mutations

WHO  said  OMICRON variant increased risk of reinfection and Cases of the new coronavirus are expected in vaccinated people, although in a small and predictable proportion.


What is the difference with the other variants? 

Its genetic profile. While the highly transmissible Delta variant has 9 mutations on the spike protein, which plays an essential role in infection, the Omicron variant has 32 mutations on this protein and about 50 in all.

It is therefore potentially more transmissible and more dangerous due to the new combination of mutations.

Will the tests and vaccines still be effective?

vaccination remains essential to reduce severe disease and death, including from the dominant Delta variant, and urges accelerated vaccination of high-priority groups.

PCR tests continue to detect infection, including by Omicron


DELTA   VS   OMICRON VARIANT

Delta was dominant but susceptible to vaccine. Omicron and Beta are more resistant some vaccines. Because beta variant can causes recurrent infections so vaccines are not as effective for recurrent infections.


Delta has 18 amino acid mutations in the 5 spike protein, and 8 residues in more than 60% of available sequence.
Omicron variant has 43 amino acid  mutations in the 5 spike protein , 34 residues in more than 60% of available sequence. Obviously Omicron is more transmissible. 

Does Omicron cause milder or more severe disease than previous variants?

Early reports linked Omicron with mild disease, raising hopes that the variant might be less severe than some of its predecessors, Omicron has lot of mutations than other variants. But severity of the variant still under investigation.




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